2019 About APS EB 2019 Information

Neural Circulatory Mechanisms Linking Sleep Loss to Hypertension

Symposium — Monday, April 8, 2019 — 8:30 AM - 10:00 AM — Convention Center, Room W311G
Neural Control and Autonomic Regulation Section — Chair: Jacqueline K Limberg — Co-Chair: Virend K Somers
Cosponsored by AJP - Heart and Circulatory Physiology

It is increasingly recognized that aberrant sleep quality and quantity may pose a significant health hazard, being associated with increased cardiovascular and non-cardiovascular morbidity and mortality. Evidence linking insufficient sleep to increased risk of hypertension is particularly compelling, with animal and human experimental models supporting population observations. Nevertheless, the underlying mechanistic pathways are yet to be defined. Although derangement of autonomic cardiovascular regulation is known to play a causative role in the generation and progression of hypertension, its contribution to blood pressure elevation due to sleep loss remains a matter of debate. This symposium will highlight current evidence on the effects of sleep deprivation on sympathetic and parasympathetic neural control of the cardiovascular system and the implications on blood pressure regulation. A translational approach will be followed, where the presentation of basic, animal research data will be integrated with findings from experimental human studies targeting healthy and clinical populations. Questions and areas that need to be further explored to better understand the impact of sleep loss on neural circulatory control and its significance for hypertension risk will be identified and discussed by the panel.

Speakers

  • Sympathoexcitatory Effects of Acute and Chronic Sleep Deprivation: Insights from Animal Research
    Monica Andersen — Department of Psychobiology, Universidade Federal de São Paulo

  • Impact of Sleep Restriction on Cardiovascular Autonomic Modulation and Blood Pressure Control in Healthy Subjects
    Naima Covassin — Department of Cardiovascular Medicine, Mayo Clinic

  • Insomnia, Short Sleep Duration, and Risk of Hypertension: Current Experimental Evidence
    Jason Carter — Department of Kinesiology and Integrative Physiology, Michigan Technological University





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