2019 About APS EB 2019 Information

Nrf2 as a Promising Target for Increasing Healthspan and Diminishing Aging-Related Chronic Diseases

Symposium — Sunday, April 7, 2019 — 3:30 PM - 5:00 PM — Convention Center, Room W312B
Environmental and Exercise Physiology Section — Chair: Karyn L Hamilton — Co-Chair:
Cosponsored by Physiological Reviews

Nuclear factor erythroid 2-related factor 2, more simply known as NFE2L2 or Nrf2, is a transcription factor often referred to as the “master regulator of antioxidant enzymes.” While aptly nick-named, gene expression regulated by Nrf2 is not limited only to antioxidant defenses, but instead extends to genes encoding proteins involved in cell cycle regulation, apoptosis, inflammation, protein turnover, and drug metabolism. Mounting evidence suggests a role for Nrf2 in modulating outcomes in models of cancer, cardiovascular diseases, metabolic diseases, neurodegenerative diseases, and other age-related chronic diseases. Recently, through the NIH Interventions Testing Program, dietary supplementation with Nrf2 activators was shown to extend median lifespan in male mice. Collectively, the body of literature suggests that Nrf2 may be a viable target for altering aging biology, decreasing the burden of age-related chronic diseases, and extending human healthspan. This symposium will review some of this body of literature with an emphasis on pharmacological/nutraceutical Nrf2 activators, exercise as a Nrf2 modulator, and the promise of Nrf2 activation for altering the pathology of cancer and neurodegenerative diseases. Dr. Karyn Hamilton will chair the session and also provide a brief overview of Nrf2 activation in the context of exercise and the cellular environment. Dr. Joe McCord will address optimizing regulation of the Nrf2 pathway. Dr. Salvatore Oddo will present on the role of Nrf2 in brain aging and neurodegeneration. Finally, Dr. Tony Ah-Ng Kong will highlight epigenetic regulation of Nrf2 in the context of cancer. In sum, this will be a one-of-a-kind symposium addressing a cellular target relevant to role of exercise, diet, and pharmacology in preventing age-related diseases and extending human healthspan.


  • Brief Overview of Nrf2 in the Context of Exercise and the Environment
    Karyn L Hamilton — Health and Exercise Science, Colorado State University

  • An Overview of Promising Phytochemical and Synthetic Nrf2 Activators: Potential for Slowed-Aging Interventions
    Joe M McCord — School of Medicine, University of Colorado School of Medicine and Pathways Bioscience

  • Nrf2 at the Crossroad Between Aging and Alzheimer’s Disease
    Salvatore Oddo — ASU-Banner Neurodegenerative Disease Research Center, Arizona State University

  • Nrf2 and Aging-Related Disease: Epigenetics and Cancer
    Tony Ah-Ng Kong — Department of Pharmaceutics Ernest Mario School of Pharmacy, Rutgers University

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