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pH Homeostasis and Acid-Base Transport

Featured Topic — Sunday, April 7, 2019 — 1:30 PM - 3:00 PM — Convention Center, Room W311A
Cell and Molecular Physiology Section — Chair: Mark Parker — Co-Chair: Michael Romero
Cosponsored by AJP - Cell Physiology

The topic of ‘pH homeostasis and acid-base transport” covers a wide variety of themes from the basis of disturbed acid-base balance (e.g. carbonic anhydrase activity in tumors), H+/CO2 sensing, the mechanisms of action and regulation of Na+/H+ exchangers, Cl-/HCO3- exchangers, Na+-HCO3- cotransporters,  H+/Lac- cotransporters, NH3/NH4+ transporters, ‘gas channels’, and H+ channels, the genetic basis of acid-base disturbances, and the pH-sensitivity of numerous other processes (e.g. renal salt handling), and novel phenotypes of acid-base transporter or acid-base sensor null mice.   The first crystal structure of the electrogenic Na+-2HCO3- cotransporter NBCe1 (SLC4A4) was recently published in Nature Communications. With the structure of the related Cl-/HCO3- exchanger (SLC4A1) also recently published it is now possible to begin to understand how  members of the same solute carrier family perform such diverse actions. With the structural basis of these activities within grasp, we are now on the verge of settling some long controversial facets of the molecular action of Na+/HCO3- transporters, such as the apparent ability to shift stoichiometry, their Cl—dependence, and pathological HCO3-independent ion leaks.

Speakers

  • CryoEM Structure of Human NBCe1
    Ira Kurtz — Division of Nephrology David Geffen School of Medicine, University of California Los Angeles

  • Abstract
    Laura Vachel — NIDCR, NIH

  • Abstract
    Phinea Z. Romero — Univ WI-Madison

  • Abstract
    Matthew Brown — Physiology and Biomedical Engineering, Mayo Clinic

  • Abstract
    Autumn N. Harris — Nephrology, University of Florida





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