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Emerging Roles of the Cytoskeleton in Striated Muscle

Symposium — Tuesday, April 9, 2019 — 1:30 PM - 3:00 PM — Convention Center, Room W311A
Cell and Molecular Physiology Section — Chair: Thomas Hawke — Co-Chair: Christopher Perry
Cosponsored by AJP - Cell Physiology and J. Appl. Physiol.

Historically, the cytoskeleton of striated muscles was viewed as a static structural scaffold.  However, in recent years the cytoskeleton has emerged as dynamic network playing functionally diverse roles in everything from metabolic regulation and mitochondrial bioenergetics to chaperone assisted autophagy.  In this Symposium, recognized leaders in the area of striated muscle cytoskeletal dynamics will come together to discuss their latest findings as they pertain to ‘emerging roles of the cytoskeleton in striated muscles’. Dr. Sandra Cooper (University of Sydney) will present her novel findings related to fragile muscle membranes. Dr. Leslie Leinwand (University of Colorado, USA) will focus her presentation on her recent work investigating sexual dimorphism in myosin myopathies. Dr. Anna Kashina (University of Pennsylvania School of Veterinary Medicine, USA) will then discuss her work in collaboration with Dr. Dilson Rassier investigating the post-translational modification of cytoskeletal proteins that regulate skeletal muscle strength. The learning objective of this symposium is to understand how changes to the striated muscle cytoskeleton can manifest into a decline or improvement in muscle health (both acutely and chronically) which can impact the outcomes of a variety of disease states (e.g. myopathies, muscular dystrophy, muscle wasting and sarcopenia, diabetes).


  • Regulating Skeletal Muscle Function through Cytoskeletal Post-Translational Modifications
    Anna Kashina — Department of Biomedical Sciences, University of Pennsylvania

  • Calpain-Driven Cytoskeletal Remodeling: A Master Regulator of Membrane Repair; the Ultimate Example of Rescuer Turning Rogue with Membrane Injury
    Sandra Cooper — KR - Kids Neuroscience Centre, The Children's Hospital at Westmead

  • Sexual Dimorphism in Cytoskeletal Regulation
    Leslie Leinwand — Molecular, Cellular and Developmental Biology, University of Colorado, Boulder

  • Co-Chair
    Christopher Perry —

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