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ENaC and Fluid Transport across Airway Epithelia

Symposium — Monday, April 8, 2019 — 3:30 PM - 5:00 PM — Convention Center, Room W311D
Respiration Section — Chair: Mike Althaus — Co-Chair: Michael Butterworth
Cosponsored by AJP - Lung Cellular and Molecular Physiology

This symposium will highlight the contribution of the epithelial sodium channel (ENaC) to airway physiology and pathophysiology. ENaC activity is known to establish osmotic gradients across the airway epithelium that regulate airway surface hydration. Deregulated ENaC activity in airway epithelia cause or exacerbate pathophysiological states like cystic fibrosis (CF) and chronic airway disease. ENaC is expressed in most of the epithelial cells lining the airways and novel roles for this channel are still being described. The focus of the symposium will be to review current research on the physiological regulation of ENaC activity in the airway. Speakers will highlight the contribution of defective regulation of this ion channel in disease states. This includes the role of proteases that are known to activate the channel, and protease inhibitors as a possible therapeutic intervention to alter ENaC function in diseases like CF. ENaC’s involvement in other chronic airway diseases will be discussed. Symposium speakers have expertise in chronic airway disease including CF and will be able to inform attendees on their latest findings linking ENaC dysregulation to these disorders and highlighting ENaC as a pharmacological target for the treatment of airway disease. 

Speakers

  • Slippery when Wet: SPLUNC1, ENaC and Airway Hydration
    Robert Tarran — Cell Biology and Physiology, University of North Carolina

  • Protease Inhibitors to Regulate ENaC and Improve Airways Hydration in Cystic Fibrosis
    Lorraine Martin — School of Pharmacy, Queen's University Belfast

  • Role of ENaC in Chronic Airway Disease
    Johanna Salomon — Translationale Pneumologie, University of Heidelberg





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