Of Mice and Men: What Have We Really Learned about the Regulation of Coronary Vascular Function in Health and Disease?

Symposium — Sunday, April 22, 2018 — 8:30 AM - 10:00 AM — Convention Center, Room 23
Cardiovascular Section — Chair: Shane Phillips — Co-Chair: Adam Goodwill

Animal models have provided excellent insight into mechanisms of vascular regulation in health and disease. However, there are unique aspects of the human microcirculation that do not correlate with findings in animal models. Numerous factors may influence the published differences in mechanisms of vasodilatory function in the human microcirculation and those of animal models. For example, the generation of the vasodilator reactive oxygen species hydrogen peroxide contributes as a flow induced vasodilator in the human coronary microcirculation during disease (Liu Y; Gutterman DD. Circ Res 108: 2011). In animal models, this mechanism of vasodilation flow appears to play less important and in some cases virtually absent.  This symposium will highlight the recent insights gained from the study of human coronary microcirculation and contrast them to state of the art knowledge in other preclinical animal models.

Speakers

• Mechanisms of vasodilation in the human coronary micro-circulation in diabetes.
  Frank Sellke — Brown Medical School


• Mechanisms of coronary flow control in swine models of health and disease.
  Adam Goodwill — Indiana University School of Medicine


• Age-related coronary microvascular dysfunction in murine models.
  Amanda Jo LeBlanc — University of Louisville School of Medicine


• Multi-scale modeling of supply-demand matching in myocardial oxygen delivery.
  Dan Beard — University of Michigan


• CHAIR
  Shane Phillips —


• COCHAIR
  Goodwill Adam —