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Origins of Cardiovascular Disease: Does Metabolic Disease Always Come First?

Featured Topic — Tuesday, April 24, 2018 — 1:30 PM - 3:00 PM — Convention Center, Room 27
Water and Electrolyte Homeostasis Section — Chair: Frank T. Spradley — Co-Chair: Aline M. A. De Souza

Cardiovascular disease is the number killer in the world, and metabolic disease is thought to be a culprit. However, there is new evidence of a synergistic action between cardiovascular and metabolic diseases to exacerbate the risk for mortality. Therefore, it is 1) important to segregate out the degree to which each of these diseases contribute to this increased risk and 2) the timing of treating one or either to prevent death from cardiovascular disease. It also seems likely that the developmental origins of metabolic disease theory is one way this increased risk for cardiovascular diseases occurs and finding the timing of treating this programmed metabolic disease is crucial.


  • Obesity, cardiometabolic and kidney dysfunction: mechanistic links.
    John E. Hall — Dept. of Physiology/BIophysics, Univ. of Mississippi Med. Ctr.

  • Early life stress induces endothelial-derived HDAC9 and ET-1 expression
    Kasi C. McPherson — University of Alabama at Birmingham

  • Sex Differences in the Development of Renal Injury in Obese Dahl Salt-Sensitive Leptin Receptor Mutant Rats During Prepubertal Obesity
    Bibek Poudel — university of Mississippi Medical Center

  • Nighttime sodium intake is associated with cardiometabolic risk and insulin resistance in night shift nurses
    Joshua S. Speed — University of Alabama at Birmingham

  • AMPK as a metabolic sensor regulates inflammatory response during ischemic insults
    Ji Li — University of Mississippi Medical Center


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