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Molecular Transducers of the Physiological Adaptations to Exercise and Aging

Symposium — Tuesday, April 24, 2018 — 1:30 PM - 3:00 PM — Convention Center, Room 25C
Environmental and Exercise Physiology Section — Chair: Douglas R Seals — Co-Chair: Christopher R Martens

Regular exercise and maintaining high cardiorespiratory fitness remain one of the most effective strategies for improving health outcomes and preventing disease risk across the lifespan.  Despite the well-established benefits of exercise, the molecular mechanisms by which these improvements occur remain largely unknown.  In response to this critical knowledge gap, the NIH has recently invested substantial resources though its Common Fund to develop the Molecular Transducers of Physical Activity Consortium (MoTrPAC) - an interdisciplinary and translational initiative designed to extensively map the molecular mechanisms by which physical activity induces health benefits and reduces disease risk.  In this timely symposium proposal entitled Molecular Transducers" of the Physiological Adaptations to Exercise and Aging, four of the leading investigators in the field will discuss the current evidence linking molecular changes to improvements in health and physiological function in response to exercise.  


  • Symposium introduction.
    Douglas R Seals — Integrative Physiology, University of Colorado Boulder

  • Molecular mechanism of reversal of age-related decline of muscle mitochondria in humans.
    Sreekumaran (Sree) Nair — Division of Endocrinology, Mayo Clinic

  • Inter-individual response heterogeneity: a window into molecular transducers of exercise adaptation.
    Marcas Bamman — Center for Exercise Medicine, University of Alabama Birmingham

  • Metabolites as key molecular transducers of exercise and metabolic capacity.
    Jane Shearer — Kinesiology, University of Calgary

  • Epigenetic patterns with aging and exercise are associated with indicators of healthpsan in humans.
    Christopher R Martens — Kinesiology & Applied Physiology, University of Delaware


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